Is heartburn keeping you up at night? Do your get acid reflux after every meal you eat? Have you tried treating your symptoms naturally with no avail? Then it may be time to try a medication for acid reflux. If your indigestion occurs daily or more than three times a week then it's recommended to start a heartburn medication. Most acid reflux medications are available over the counter (OTC), but if symptoms of heartburn persist then it may be time to check in with your doctor as this maybe indicative of a much more serious problem than indigestion.